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Updated: May 3, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
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Sphingosine kinase 1 regulates measles virus replication.
Madhuvanthi Vijayan1, Young-Jin Seo1, Curtis John Pritzl1
1Departments of Surgery & Molecular Microbiology and Immunology, University of Missouri-Columbia, Columbia, MO 65212, USA.
Virology
|February 8, 2014
Summary
Sphingosine kinase (SK) inhibition restricts measles virus (MV) replication by impacting viral protein synthesis. This study reveals SK as a critical host factor essential for efficient MV propagation and NF-κB pathway activation.
Area of Science:
- Virology
- Cell Biology
- Biochemistry
Background:
- Measles virus (MV) relies on host factors for replication.
- Sphingosine kinase (SK) regulates cellular processes, including host defense.
Purpose of the Study:
- To investigate the role of Sphingosine Kinase 1 (SK1) in measles virus replication.
- To determine if SK inhibition affects MV propagation and associated signaling pathways.
Main Methods:
- Overexpression and inhibition of SK1 in cells expressing MV receptors (SLAM, Nectin-4).
- Assessed viral protein expression and infectious virus production.
- Investigated the impact of SK inhibition on NF-κB signaling pathway activation.
Main Results:
- SK1 overexpression enhanced MV replication.
- SK inhibition impaired viral protein expression and infectious virus production across different MV strains.
- SK inhibition suppressed MV-induced NF-κB activation.
- NF-κB pathway inhibition also repressed MV protein synthesis.
Conclusions:
- Sphingosine kinase (SK) is a crucial host factor for efficient measles virus replication.
- SK inhibition restricts MV replication, partly by modulating the NF-κB signaling pathway.
- Targeting SK represents a potential strategy for antiviral therapies against measles.
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