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Vasoactive intestinal peptide (VIP) induces a K+ current in the Xenopus oocyte membrane
V Reale1, M L Ashford, E A Barnard
1MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, U.K.
Neuroscience Letters
|December 16, 1987
Abstract:
Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is dose-dependent, with a threshold near 10(-9)M VIP. The effect is potentiated by forskolin. Of several other types of neuropeptide tested, only avian pancreatic polypeptide gives a response: this is similar to that of VIP, but this peptide can also potentiate the response to VIP.