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Related Concept Videos

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Loss of Tumor Suppressor Gene Functions

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis.

Alan Fu1, Aaron E Hoffman2, Ran Liu3

  • 1Department of Environmental Health Sciences; Yale School of Public Health; New Haven, CT USA.

Epigenetics
|February 8, 2014
PubMed
Summary

This study links microRNA-618 (miR-618) to follicular lymphoma, a type of non-Hodgkin lymphoma. A specific genetic variant in miR-618 is associated with increased lymphoma risk and altered miR-618 expression, suggesting it as a potential biomarker and therapeutic target.

Keywords:
follicular lymphomalymphomagenesismiR-618pathway analysistargetome

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) play crucial roles in cancer, but their specific involvement in non-Hodgkin lymphoma (NHL) requires further elucidation.
  • Understanding the molecular basis of miRNA-cancer associations is vital for developing targeted therapies.

Purpose of the Study:

  • To investigate the association between microRNA-618 (miR-618) and non-Hodgkin lymphoma (NHL) at both population and molecular levels.
  • To identify miR-618 targets and assess the functional impact of a single nucleotide polymorphism (SNP) in miR-618 on lymphoma development.

Main Methods:

  • Utilized a high-throughput RIP-Chip assay to identify miR-618 targets.
  • Performed gene network analysis to determine the functional relevance of identified targets.
  • Conducted a population-based case-control study to genotype a miR-618 stem-loop SNP (rs2682818) in NHL patients and controls.
  • Performed in vitro analyses to evaluate the functional impact of the SNP on miR-618 expression.

Main Results:

  • Identified 128 miR-618 targets, enriched in lymphoma-relevant pathways.
  • Found a significant association between the miR-618 SNP (rs2682818 G>T) and follicular lymphoma (FL) risk (OR: 1.65).
  • Demonstrated that the variant T allele of rs2682818 reduces mature miR-618 levels, potentially disrupting miR-618-regulated pathways.

Conclusions:

  • miR-618 is implicated in follicular lymphomagenesis.
  • miR-618, influenced by the rs2682818 SNP, serves as a potential risk biomarker for follicular lymphoma.
  • miR-618-regulated pathways represent potential therapeutic targets for follicular lymphoma.