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Updated: May 3, 2026

Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR

Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR

Published on: November 23, 2012

Comparative genomic hybridization identifies virulence differences in Streptococcus suis.

Han Zheng¹, Ruiting Lan², Xiao Zheng¹

¹Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.

|February 8, 2014

Summary

Streptococcus suis strains show significant genetic variation, impacting their virulence. This study classified S. suis into three groups based on virulence levels, aiding in identifying dangerous strains.

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Last Updated: May 3, 2026

Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR

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Published on: November 23, 2012

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR

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Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Published on: July 1, 2018

Area of Science:

Veterinary Microbiology
Genomics
Infectious Diseases

Background:

Streptococcus suis is a significant zoonotic pathogen with high species diversity, complicating the identification of virulent strains.
Understanding the genetic basis of virulence is crucial for controlling S. suis infections.

Purpose of the Study:

To investigate the genetic differences among Streptococcus suis strains.
To correlate genetic variations with virulence phenotypes in vitro and in vivo.
To classify S. suis strains based on their virulence levels.

Main Methods:

Comparative genomic hybridization (CGH) was employed to assess genetic diversity.
In vitro assays evaluated the activation of Toll-like receptor 2/6 (TLR2/6) and resistance to phagocytosis.
In vivo studies assessed cytokine production and survival rates.

Main Results:

Distinct clades of S. suis exhibited varying abilities to activate TLR2/6 and resist phagocytosis.
Significant differences in in vivo cytokine induction and survival were observed among clades.
S. suis strains were successfully classified into three virulence groups: epidemic/highly virulent (clade Ia), virulent (clade Ib), and intermediate/weakly virulent (other clades).

Conclusions:

Genomic variation significantly influences the virulence of Streptococcus suis.
The classification into three virulence groups provides a framework for identifying and managing S. suis infections.
This study enhances our understanding of the genomic and virulence diversity within S. suis populations.