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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280
Allergic Reactions02:06

Allergic Reactions

26.4K
Overview
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Cross-reactivity00:42

Cross-reactivity

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Overview
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Related Experiment Video

Updated: May 3, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

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Food-dependent exercise-induced anaphylaxis with negative allergy testing.

Jacob Kleiman1, Moshe Ben-Shoshan

  • 1Department of Medicine, McGill University, Montreal, Canada.

BMJ Case Reports
|February 8, 2014
PubMed
Summary

Food-dependent exercise-induced anaphylaxis (FDEIA) can occur even with normal allergy tests. This case highlights diagnostic challenges for this rare condition.

Area of Science:

  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Food-dependent exercise-induced anaphylaxis (FDEIA) is a rare condition.
  • It involves anaphylaxis triggered by exercise after consuming a specific food.
  • Both exercise and food are tolerated independently.

Observation:

  • Diagnosis relies on clinical history and food-exercise challenges.
  • Standard tests like skin prick testing (SPT) and serum-specific IgE may be negative.
  • A case of FDEIA with negative SPT and IgE is presented.

Findings:

  • The presented case demonstrated FDEIA despite negative results in standard allergy testing.
  • An open food-exercise challenge was crucial for diagnosis.
  • This highlights limitations of current diagnostic methods for FDEIA.

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Last Updated: May 3, 2026

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Basophil Activation Test for Allergy Diagnosis
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Implications:

  • Challenges in diagnosing and managing FDEIA are emphasized.
  • Physicians should consider FDEIA even with negative specific IgE and SPT.
  • Further research may be needed to improve FDEIA diagnostic accuracy.