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Switch-associated protein 70 antibodies in multiple sclerosis: possible association with disease progression
Recai Türkoğlu1, Mehmet Gencer, Duygu Ekmekçi
1Department of Neurology, Haydarpasa Numune Education and Research Hospital, Istanbul University, Istanbul, Turkey.
Objective:
This study was conducted to identify a biomarker for multiple sclerosis (MS) that can be used as a predictor of relapse and disability.
Materials And Methods:
Sera of 26 consecutive relapsing-remitting MS (RRMS) patients were screened for switch-associated protein 70 (SWAP-70) antibody, which was previously identified by protein macroarray. The serum levels of several cytokines, chemokines and soluble adhesion molecules related to MS attacks were measured by enzyme-linked immunosorbent assay (ELISA). A possible correlation was sought among levels of SWAP-70 antibody, measured humoral factors and disability scores.
Results:
ELISA studies showed high-titre SWAP-70 antibodies in 16 (61.5%) RRMS sera obtained during the attack period and 9 (34.6%) sera obtained during remission. There was a significant inverse correlation between SWAP-70 antibody levels and expanded disability status scale scores, CXCL10, soluble VCAM-1, CXCL13 and soluble VLA-4 levels.
Conclusion:
Our results showed that SWAP-70 antibodies could potentially be utilized as relapse and prognostic biomarkers in MS. Whether or not SWAP-70 antibodies have any effect on disease mechanisms requires further investigation.
Insights
Researchers identified switch-associated protein 70 (SWAP-70) antibodies as potential biomarkers for predicting multiple sclerosis (MS) relapses and disability progression. Higher SWAP-70 antibody levels correlated with better outcomes in MS patients.
Area of Science:
- Neuroimmunology
- Biomarker Discovery
- Multiple Sclerosis Research
Background:
- Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
- Predictive biomarkers for MS relapses and disability are crucial for effective patient management.
- Switch-associated protein 70 (SWAP-70) antibody was previously identified as a potential factor in MS.
Purpose of the Study:
- To identify a reliable biomarker for predicting multiple sclerosis (MS) relapse and disability.
- To investigate the correlation between SWAP-70 antibody levels and MS disease activity.
Main Methods:
- Screening of sera from 26 relapsing-remitting MS (RRMS) patients for SWAP-70 antibodies.
- Measurement of serum cytokines, chemokines, and soluble adhesion molecules using ELISA.
- Correlation analysis between SWAP-70 antibody levels, humoral factors, and disability scores.
Main Results:
- High-titre SWAP-70 antibodies were detected in 61.5% of RRMS patients during attacks and 34.6% during remission.
- A significant inverse correlation was observed between SWAP-70 antibody levels and disability scores (EDSS).
- SWAP-70 antibody levels showed inverse correlations with CXCL10, VCAM-1, CXCL13, and VLA-4.
Conclusions:
- SWAP-70 antibodies show potential as biomarkers for MS relapse and prognosis.
- Further research is needed to elucidate the role of SWAP-70 antibodies in MS disease mechanisms.
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