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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
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Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
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Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

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Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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New therapies for allergic rhinitis.

Fulvio Braido1, Francesca Sclifò, Matteo Ferrando

  • 1Allergy & Respiratory Diseases Clinic - DIMI, University of Genoa, IRCCS AOU San Martino-IST, Pad. Maragliano, Largo Rosanna Benzi 10, 16132, Genova, Italy, fulvio.braido@unige.it.

Current Allergy and Asthma Reports
|February 8, 2014
PubMed
Summary

New treatments for allergic rhinitis are emerging, offering improved efficacy and safety beyond current standards. This review highlights recent advancements and ongoing research in managing allergic rhinitis effectively.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology

Background:

  • Allergic rhinitis significantly impacts patients' quality of life and is linked to asthma.
  • Current first-line treatments include second-generation antihistamines and inhaled steroids.
  • Effective management requires exploring novel and safer therapeutic options.

Purpose of the Study:

  • To provide an updated review of allergic rhinitis treatments.
  • To focus on clinical trials from the past 20 months.
  • To assess the efficacy and safety of new drug formulations and molecules.

Main Methods:

  • Review of recent clinical trials on allergic rhinitis treatments.
  • Analysis of new formulations of existing drugs.
  • Investigation of novel therapeutic molecules and targets.

Main Results:

  • New drug formulations (e.g., oral solutions, fast-dissolving tablets, combination therapies) show promise.
  • Emerging molecules like ciclesonide, bilastine, and PDE4 inhibitors are under investigation.
  • Immunologic targets (e.g., omalizumab) and unconventional treatments are also being explored.

Conclusions:

  • The landscape of allergic rhinitis treatment is evolving with new formulations and molecules.
  • Ongoing research aims to enhance treatment efficacy and safety.
  • These advancements represent a new frontier in managing allergic rhinitis.