Calcium channel antagonists and renin release
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Updated: Oct 21, 2026

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
Published on: June 27, 2015
1Department of Physiology, Wayne State University School of Medicine, Detroit, Mich.
Abstract:
Calcium (Ca2+) is an inhibitory second messenger in the renin secretory process, and evidence suggests that first messengers can alter Ca2+ in the renin-secreting juxtaglomerular cells by altering Ca2+ influx, efflux, and mobilization pathways. Influx of Ca2+ through voltage-operated channels is one such pathway, and it has been suggested that pressure-induced changes in renin secretion (the baroreceptor mechanism) are mediated by depolarization-induced Ca2+ influx. On this basis, renin secretion should be stimulated by organic calcium channel antagonists; however, stimulation is only occasionally observed. Therefore, other effects of these substances counteract the stimulatory effects on renin secretion.
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