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[Sleep disorders and quality of life in refractory partial epilepsy: results of the SLEEP study]
Irene García-Morales1, Antonio Gil-Nagel, Jesús de Rosendo
1Hospital Clinico San Carlos, 28040 Madrid, Espana.
Introduction:
Sleep disorders are frequent among patients with epilepsy and are correlated with a poorer quality of life.
Aims:
To evaluate the prevalence of sleep disorders in patients with refractory and non-refractory focal epilepsy, and to explore the influence of these alterations on the quality of life of these patients.
Patients And Methods:
An epidemiological, controlled, cross-sectional study was conducted in 150 outpatient neurology services. Patients who had been treated with two antiepileptic drugs since the onset of the disease (18-55 years) were recruited for the study.
Results:
The sample included 237 patients with non-refractory focal epilepsy and 264 patients with refractory focal epilepsy. Twenty-two per cent of the non-refractory epilepsy group and 45% of the group with refractory epilepsy (p < 0.0001) suffered from some sleep disorder. The patients with refractory epilepsy had a poorer quality of life (p < 0.001) as measured with the quality of life questionnaire QOLIE-10. A positive significant correlation was observed between quality of life and quality of sleep, in both chronic insomnia (r = 0.65; p < 0.0001) and excessive daytime sleepiness (r = 0.43; p < 0.0001).
Conclusions:
Sleep disorders are more frequent in refractory than in non-refractory epilepsy, and affect the patients' quality of life.
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