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Updated: May 3, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
Published on: August 22, 2016
Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine
Abhigyan Satyam1, Pramod Kumar, Xingliang Fan
1Network of Excellence for Functional Biomaterials (NFB), National University of Ireland Galway, (NUI Galway), Galway, Ireland.
Abstract:
MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM-rich living substitutes.
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