Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Localization of the rubella E1 epitopes.

G M Terry1, L Ho-Terry, P Londesborough

  • 1Department of Chemical Pathology, University College and Middlesex Hospital Medical School, London, U.K.

Archives of Virology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions.

British journal of cancer·2006
Same author

The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions.

British journal of cancer·2004
Same author

Abnormal FHIT expression profiles in cervical intraepithelial neoplastic (CIN) lesions.

British journal of cancer·2002
Same author

Detection of high-risk HPV types by the hybrid capture 2 test.

Journal of medical virology·2001
Same author

The construction of defective interfering rubella virus particles.

Archives of virology·2000
Same author

Dopamine release in the amygdaloid complex of the rat, studied by brain microdialysis.

Neuroscience letters·1998

Researchers identified three key areas on the rubella virus E1 glycoprotein. These epitopes are crucial for triggering immune responses, specifically haemagglutination inhibition and neutralizing antibodies.

Area of Science:

  • Virology
  • Immunology
  • Structural Biology

Background:

  • Rubella virus is a significant human pathogen.
  • The envelope glycoprotein E1 (rubella virus) plays a critical role in viral entry and is a target for neutralizing antibodies.

Purpose of the Study:

  • To identify specific regions on the rubella virus E1 glycoprotein that are recognized by neutralizing antibodies.
  • To map the location of epitopes involved in haemagglutination inhibition and neutralization.

Main Methods:

  • Bioinformatics analysis of the predicted amino acid sequence of rubella virus E1 glycoprotein.
  • Epitope mapping using serological assays (haemagglutination inhibition and neutralization assays).

Main Results:

Related Experiment Videos

  • Three distinct epitopes were identified within the amino acid sequence of rubella virus E1 glycoprotein.
  • These epitopes are located between amino acids 245-285.
  • The identified epitopes effectively react with both haemagglutination inhibition and neutralizing antibodies.

    • Conclusions:

    • The region between amino acids 245-285 of rubella virus E1 glycoprotein contains critical epitopes.
    • These epitopes are important targets for developing rubella virus vaccines and diagnostics.
    • Understanding these epitopes can aid in the design of more effective antiviral strategies.