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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Wholemount Immunohistochemistry for Revealing Complex Brain Topography
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Surface smoothing: a way back in early brain morphogenesis.

Julien Lefèvre1, Victor Intwali2, Lucie Hertz-Pannier3

  • 1Aix-Marseille Univ, Departement d'Informatique et Interractions, Marseille, France. julien.lefevre@univ-amu.fr

Medical Image Computing and Computer-Assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
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This study models early brain development, comparing cortical folding to smoothing processes. The findings offer insights into brain surface development in preterm infants.

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Area of Science:

  • Neuroscience
  • Computational Biology
  • Developmental Biology

Background:

  • Early brain development involves complex cortical folding.
  • Understanding this process is crucial for identifying developmental abnormalities.
  • Cortical smoothing by mean curvature flow offers a potential mathematical model.

Purpose of the Study:

  • To investigate the analogy between early cortical folding and smoothing via mean curvature flow.
  • To develop and validate a computational model for cortical development trajectories.
  • To analyze geometrical indices of cortical surfaces in preterm newborns.

Main Methods:

  • Introduction of a one-parameter model for developmental trajectories using Volume-Area plots.
  • Development of an efficient optimization strategy for parameter estimation.
  • Validation on 40 cortical surfaces of preterm newborns, comparing geometrical indices and central sulcus trajectories.

Main Results:

  • The proposed model successfully fits developmental trajectories.
  • Efficient parameter estimation strategies were established.
  • Model validation demonstrated its utility in analyzing preterm infant cortical surfaces.

Conclusions:

  • The study establishes a link between early cortical folding and mean curvature flow.
  • The developed model provides a quantitative tool for studying brain development.
  • Findings contribute to understanding neurodevelopmental trajectories in preterm infants.