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Related Experiment Video

Updated: May 3, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Multiple myeloma with bilateral humerus location. Case report.

O Alexa¹, B Veliceasa¹

¹Discipline of Orthopedics and Traumatology, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, Iasi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi

|February 11, 2014

Summary

This summary is machine-generated.

Multiple myeloma, a plasma cell cancer, can present with atypical symptoms. Pathological examination is crucial for accurate diagnosis when initial tests are inconclusive.

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Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

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Published on: April 15, 2022

Area of Science:

Hematologic Malignancies
Oncology
Plasma Cell Disorders

Background:

Multiple myeloma (Kahler's disease/myelomatosis) is the second most common hematologic malignancy, originating in plasma cells.
It represents 13% of hematologic cancers and 1% of all cancer diagnoses.
The CRAB mnemonic (Calcium, Renal failure, Anemia, Bone lesions) outlines common diagnostic criteria.

Observation:

A case report details a 70-year-old male with bilateral humeral multiple myeloma.
Diagnostic challenges arose from atypical X-ray findings, deviating from classic 'punched-out' bone lesions.
Erythrocyte Sedimentation Rate (ESR), blood, renal, and liver function tests also yielded atypical results.

Findings:

The presented case highlights diagnostic variability in multiple myeloma.
Atypical radiological and laboratory findings complicated the initial diagnostic process.
Pathological examination ultimately confirmed the diagnosis in this challenging case.

Implications:

While generally diagnosed via blood, kidney, and X-ray tests, multiple myeloma diagnosis can be complex.
Pathological examination remains essential for definitive diagnosis in atypical presentations.
This case underscores the importance of considering pathological confirmation when standard diagnostic methods are inconclusive.