Research studies on the quality of bio-mucoadhesive tablets containing miconazole nitrate

Biomucoadhesive tablets are widely used to formulate topical antifungal drugs for treating acute oral candidiasis. The research focuses on the pharmaco-technological control of certain bio-mucoadhesive tablets containing miconazole nitrate, formulas developed and prepared by the authors based on the original formulas. The analyzed parameters were: macroscopic aspect, physical-chemical (pH) and pharmacotechnical properties (hardness, friability, mass uniformity, in vitro disintegration).The used methods are described in literature, most of them included in the Romanian and European Pharmacopoeia. The obtained results allow us to conclude that of the five original formulas, two (formulas IV and V) meet the criteria for oral mucosa drug by their tolerance (pH 5.77 to 5.84) and retention time (65-90 min.), the intimate contact of the tablet with the oral mucosa determining a high concentration of active substance.