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Mathematical modeling of the effect of boosting tumor infiltrating lymphocyte in immunotherapy

Agus Kartono1, Subiyanto1

  • 1Laboratory for Theoretical and Computational Physics, Department of Physics, Faculty of Mathematical and Natural Sciences, Bogor Agricultural University (IPB) Jalan Meranti, Building Wing S, 2nd Floor, Kampus IPB Darmaga, Bogor 16680, Indonesia.

Pakistan Journal of Biological Sciences : PJBS
|February 11, 2014
PubMed

This study, we analyzed the effect of boosting tumor infiltrating lymphocyte in immunotherapy using mathematical modeling. In this model, tumor growth is described as a tumor cells population with immunotherapy. This model also describes the effect of Tumor Infiltrating Lymphocytes (TIL), interleukin-2 (IL-2) and interferon alpha (INF-alpha) on dynamics of tumor cells. Numerical modeling of immunotherapy with or not boosted Tumor Infiltrating Lymphocyte (TIL) are presented in this study. We obtained that boosting Tumor Infiltrating Lymphocyte (TIL) in immunotherapy have a very significant role in killing of tumor cells.

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