Related Experiment Video
Updated: May 3, 2026
07:02
Animal Model of Implant-Associated Infections in Mice
Published on: June 27, 2025
1.2K
Role of infections
Kamen Rangelov1, Sanjay Sethi2
1Pulmonary and Critical Care Medicine, University at Buffalo, SUNY, 3435 Main Street, Buffalo, NY 14214, USA.
Clinics in Chest Medicine
|February 11, 2014
Summary
Infections play a key role in the development and progression of chronic obstructive pulmonary disease (COPD). This review examines how respiratory pathogens and immune responses impact COPD pathogenesis, exacerbations, and pneumonia.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Immunology
Background:
- Chronic obstructive pulmonary disease (COPD) is a major global health issue.
- Infections are increasingly recognized as significant contributors to COPD pathogenesis.
- Understanding the interplay between pathogens and host immunity is crucial for managing COPD.
Purpose of the Study:
- To review the current literature on the role of infection in COPD.
- To explore the impact of infections on stable COPD, exacerbations, and pneumonia.
- To elucidate the complex host-pathogen interactions in COPD.
Main Methods:
- Systematic literature review.
- Analysis of current research on respiratory pathogens and COPD.
- Synthesis of findings on immune responses in COPD infections.
Main Results:
- Infections are integral to COPD pathogenesis, affecting stable disease and exacerbations.
- Specific respiratory pathogens contribute to disease progression and severity.
- Host immune defenses are critically involved in the clinical presentation of COPD infections.
Conclusions:
- Infection is a key driver in the pathogenesis of chronic obstructive pulmonary disease.
- Further research into host-pathogen interactions can inform novel therapeutic strategies.
- Managing infections is essential for improving outcomes in patients with COPD.
Related Concept Videos
01:20Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
01:26Factors Affecting the Risk of Infection
14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
5.7K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.7K
01:22Healthcare Associated Infections II: Preventive Measures
4.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.7K
01:25Colonisation of Pathogens
77
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
77
01:26Stages of Infection
70.2K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
70.2K