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Systemic necrotizing vasculitis induced by isoniazid.

Carmela D Tan1, Amber Smith1, E Rene Rodriguez1

  • 1Department of Anatomic Pathology, The Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|February 11, 2014
PubMed
Summary
This summary is machine-generated.

This case report details a rare fatal outcome of vasculitis, specifically antineutrophil cytoplasmic antibody-positive vasculitis, triggered by the medication isoniazid. It highlights a severe adverse reaction to this common tuberculosis drug.

Keywords:
ANCAIsoniazidVasculitis

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Area of Science:

  • Internal Medicine
  • Rheumatology
  • Pharmacology

Background:

  • Isoniazid is a primary medication for tuberculosis treatment.
  • Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a group of autoimmune diseases.
  • Drug-induced vasculitis is an uncommon but serious complication.

Observation:

  • A patient developed severe symptoms consistent with vasculitis.
  • The patient was undergoing treatment with isoniazid for tuberculosis.
  • Diagnostic tests confirmed the presence of antineutrophil cytoplasmic antibodies.

Findings:

  • The patient's condition was diagnosed as isoniazid-induced ANCA-positive vasculitis.
  • The vasculitis led to a fatal outcome in this rare case.
  • Causality between isoniazid and the development of vasculitis was established.

Implications:

  • This case underscores the potential for isoniazid to induce severe autoimmune vasculitis.
  • Clinicians should consider drug-induced vasculitis in patients on isoniazid presenting with relevant symptoms.
  • Further vigilance and research into rare adverse drug reactions are warranted.