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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Vertex-based morphometry in euthymic bipolar disorder implicates striatal regions involved in psychomotor function.

Benny Liberg1, Carl Johan Ekman1, Carl Sellgren1

  • 1Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden.

Psychiatry Research
|February 11, 2014
PubMed
Summary

Patients with bipolar disorder (BD) show altered right putamen shape, even without psychomotor disturbances. This suggests underlying brain changes in BD impacting executive and motor functions.

Keywords:
Basal gangliaBipolar disorderMagnetic resonance imagingPsychomotor performanceShape analysisVolumetry

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Bipolar disorder (BD) is often associated with psychomotor disturbances.
  • The basal ganglia and thalamus are critical for motor control and executive functions.

Purpose of the Study:

  • To investigate morphometric changes in the basal ganglia and thalamus in euthymic bipolar disorder patients.
  • To determine if psychomotor performance correlates with structural brain changes in bipolar disorder.

Main Methods:

  • Structural magnetic resonance imaging (sMRI) and vertex-based morphometry were used.
  • Euthymic bipolar disorder patients (n=27) and healthy controls (n=27) were compared.
  • Motor performance was assessed, and brain structure (volume and shape) was analyzed.

Main Results:

  • No significant differences in motor performance were found between groups.
  • A significant difference in the shape of the right putamen was observed in bipolar disorder patients.
  • The association between putamen shape and motor performance seen in controls was absent in bipolar disorder patients.

Conclusions:

  • Euthymic bipolar disorder patients exhibit shape alterations in the right putamen, a region involved in executive and motor functions.
  • These structural changes occur independently of observable psychomotor disturbances.
  • Other brain regions may compensate for these changes, maintaining similar motor performance levels.