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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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Related Experiment Video

Updated: May 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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[Medicines reconciliation in critically ill patients].

C Lopez-Martin1, I Aquerreta2, V Faus1

  • 1Área de Farmacia y Nutrición. AS Hospital Costa del Sol, Marbella, Málaga, España.

Medicina Intensiva
|February 11, 2014
PubMed
Summary

Medication reconciliation errors occur in nearly half of intensive care unit (ICU) patients, primarily drug omissions. Pharmacist interventions significantly improve patient safety in the ICU.

Keywords:
ConciliaciónCritically ill patientsErrores de medicaciónMedication errorsMedicines reconciliationPaciente críticoPatient safetySeguridad del paciente

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Area of Science:

  • Pharmacovigilance
  • Clinical Pharmacy
  • Patient Safety

Context:

  • Medicines reconciliation is crucial for patient safety.
  • Limited data exists on its impact in critically ill patients.
  • This study evaluates a pharmacist-led reconciliation program in the Intensive Care Unit (ICU).

Purpose:

  • To assess the incidence and characteristics of medication reconciliation errors in critically ill patients.
  • To evaluate pharmacist interventions and physician acceptance during the reconciliation process.
  • To determine the clinical significance and severity of identified medication errors.

Summary:

  • A prospective study of 50 ICU patients found that 48% had at least one medication reconciliation error, with drug omissions (74%) being most common, particularly antihypertensives.
  • 58% of errors were classified as severity category D.
  • Pharmacists intervened in 98% of discrepancies, with 81% accepted by physicians.

Impact:

  • Medication reconciliation errors in the ICU share similarities with non-critical care settings, affecting clinically significant drugs.
  • Findings support implementing medication reconciliation protocols for critically ill patients.
  • ICU pharmacists are well-positioned to conduct medication reconciliation effectively.