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The T11(3) epitope of the CD2 molecule, sheep erythrocytes, and the alternative T-cell activation pathway
H S Warren1, V McPhun, A Bezos
1Cancer Research Unit, Woden Valley Hospital, Australian Capital Territory.
In this study, results are presented showing that the T11(3) epitope of the CD2 molecule is expressed on unfractionated peripheral blood mononuclear cells, resting T cells and activated T cells. T11(3) is not therefore, an activation-specific CD2 epitope. Sheep erythrocytes (SRC) which present a cell-surface ligand for CD2 could not effectively replace anti-T11(2) in initiating proliferation of resting T cells, stimulated by anti-T11(3). SRC with either of these anti-CD2 monoclonal antibodies did activate resting T cells, but proliferation required the presence of added IL-2.
In this study, results are presented showing that the T11(3) epitope of the CD2 molecule is expressed on unfractionated peripheral blood mononuclear cells, resting T cells and activated T cells. T11(3) is not therefore, an activation-specific CD2 epitope. Sheep erythrocytes (SRC) which present a cell-surface ligand for CD2 could not effectively replace anti-T11(2) in initiating proliferation of resting T cells, stimulated by anti-T11(3). SRC with either of these anti-CD2 monoclonal antibodies did activate resting T cells, but proliferation required the presence of added IL-2.