Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

2.9K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
2.9K
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

5.0K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.0K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

8.8K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.8K
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

6.5K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
6.5K
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

16.4K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
16.4K
Endocrine Signaling01:45

Endocrine Signaling

53.7K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
53.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aberrant Ca(2+) signalling through acidic calcium stores in pancreatic acinar cells.

Cell calcium·2011
Same author

Fatty acids, alcohol and fatty acid ethyl esters: toxic Ca2+ signal generation and pancreatitis.

Cell calcium·2009
Same author

Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2009
Same author

Mitochondrial injury in pancreatitis.

Cell calcium·2008
Same author

Janus a god with two faces: death and survival utilise same mechanisms conserved by evolution.

Cell death and differentiation·2007
Same author

Calcium signalling and pancreatic cell death: apoptosis or necrosis?

Cell death and differentiation·2007

Related Experiment Video

Updated: May 3, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED
09:32

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED

Published on: May 7, 2013

18.5K

Calcium signalling and secretory epithelia.

O H Petersen1

  • 1MRC Secretory Control Research Group, Cardiff School of Biosciences, Cardiff University, The Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, Wales, UK.

Cell Calcium
|February 11, 2014
PubMed
Summary

Calcium (Ca2+) is a key intracellular regulator in secretory epithelia, controlling fluid, electrolyte, and macromolecule secretion. This review highlights unique Ca2+ signaling features in these cells, differing from endocrine glands.

Keywords:
CalciumEpitheliaSecretionSignal-transduction mechanisms

More Related Videos

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions
08:01

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Published on: January 19, 2024

2.0K
Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
12:30

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

14.2K

Related Experiment Videos

Last Updated: May 3, 2026

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED
09:32

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED

Published on: May 7, 2013

18.5K
Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions
08:01

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Published on: January 19, 2024

2.0K
Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
12:30

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

14.2K

Area of Science:

  • Cellular Biology
  • Physiology

Background:

  • Calcium ions (Ca2+) are critical intracellular regulators in diverse cell types.
  • Ca2+ signaling plays a vital role in controlling secretion in secretory epithelia.

Purpose of the Study:

  • To provide background on Ca2+ signaling concepts in epithelia.
  • To highlight general features of Ca2+ signaling in secretory epithelia, contrasting them with endocrine glands.

Main Methods:

  • Literature review and synthesis of existing research.
  • Focus on exocrine cells, particularly pancreatic acinar cells, as model systems.

Main Results:

  • Ca2+ signaling is essential for regulating fluid, electrolyte, and macromolecule secretion.
  • Ca2+ signaling in secretory epithelia exhibits distinct characteristics compared to other cell types.

Conclusions:

  • Pancreatic acinar cells offer detailed insights into Ca2+ transport mechanisms.
  • Understanding Ca2+ signaling in epithelia is crucial for comprehending secretory processes.