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Arthritis and prolactin: a phylogenetic viewpoint
Norma Adán1, María G Ledesma-Colunga1, Ana L Reyes-López1
1Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, 76230 Querétaro, Mexico.
General and Comparative Endocrinology
|February 11, 2014
Summary
Arthritis affects vertebrates, with prolactin (PRL) influencing joint inflammation. This review explores PRL
Area of Science:
- Comparative immunology
- Endocrinology
- Vertebrate biology
Background:
- Arthritic disorders are ancient, multifactorial diseases causing chronic joint inflammation.
- Genetic, environmental, and gender factors contribute to arthritis etiology.
- Prolactin (PRL) is a conserved, sexually dimorphic hormone with diverse actions across vertebrates.
Purpose of the Study:
- To review the presence and characteristics of arthritis in vertebrates.
- To examine the effects of prolactin on joint tissues and immune cells.
- To investigate prolactin's potential role in the ubiquity of arthritis.
Main Methods:
- Comparative analysis of arthritic disorders across vertebrate species.
- Review of existing literature on prolactin's functions in immune and joint tissues.
- Exploration of prolactin's evolutionary conserved actions.
Main Results:
- Arthritis is prevalent across vertebrate evolution.
- Prolactin exhibits both pro- and anti-arthritic effects depending on context.
- Prolactin's conserved functions suggest a significant role in arthritis development.
Conclusions:
- Prolactin is a key biologically conserved factor in arthritis pathogenesis.
- Understanding prolactin's role offers insights into arthritis treatment.
- A comparative approach is valuable for studying arthritis and hormone function.
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