Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 3, 2026

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

7.9K

Spatial patterns of fixation-switch behavior in strabismic monkeys.

Mehmet N Agaoglu1, Stephanie K LeSage, Anand C Joshi

  • 1College of Optometry, University of Houston, Houston, Texas.

Investigative Ophthalmology & Visual Science
|February 11, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dose-Response Characteristics of Retinal Inactivation Due to Intravitreal Injections of Tetrodotoxin in Nonhuman Primates.

Investigative ophthalmology & visual science·2026
Same author

Relationship between form-deprivation myopia and amblyopic deficit.

Vision research·2026
Same author

Neural Innervation of Cyclovertical Extraocular Muscles During Asymmetric Vertical Vergence.

Investigative ophthalmology & visual science·2026
Same author

Cross-species lesion mapping links a midbrain circuit to vergence dysfunction.

Brain : a journal of neurology·2025
Same author

Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters.

Nature communications·2024
Same author

An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models.

Nature communications·2024
Same journal

Impact of Subretinal Drusenoid Deposits on Ellipsoid Zone-Related Thickness Metrics.

Investigative ophthalmology & visual science·2026
Same journal

Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis.

Investigative ophthalmology & visual science·2026
Same journal

Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

Investigative ophthalmology & visual science·2026
Same journal

Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

Investigative ophthalmology & visual science·2026
Same journal

The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

Investigative ophthalmology & visual science·2026
Same journal

Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

Investigative ophthalmology & visual science·2026
See all related articles

Strabismic monkeys exhibit spatial fixation-switch behavior, demonstrating a flexible visual system that can choose which eye to use for target acquisition. This adaptability suggests the brain weighs retinal error signals from both eyes when deciding fixation.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Vision Science

Background:

  • Strabismus involves perceptual suppression of one eye to prevent double vision.
  • This suppression is linked to fixation-switch behavior, where eye usage depends on target location.
  • Understanding these spatial patterns is crucial for strabismus research.

Purpose of the Study:

  • To investigate the spatial patterns of fixation-switch behavior in monkeys with strabismus.
  • To analyze how strabismic monkeys utilize different eyes for fixation based on target presentation.
  • To explore the underlying mechanisms of visual suppression and eye-switching in strabismus.

Main Methods:

  • Recorded eye movements in exotropic and esotropic monkeys during a binocular saccade task.
Keywords:
eye movementsmonkeysstrabismusvisual fixationvisual suppression

More Related Videos

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

4.0K
Eye Movement Monitoring of Memory
08:06

Eye Movement Monitoring of Memory

Published on: August 15, 2010

14.4K

Related Experiment Videos

Last Updated: May 3, 2026

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings
07:08

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

7.9K
Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

4.0K
Eye Movement Monitoring of Memory
08:06

Eye Movement Monitoring of Memory

Published on: August 15, 2010

14.4K
  • Analyzed spatial fixation patterns by calculating the incidence of using each eye for targets at various gaze locations.

    • Main Results:

    • Observed spatial fixation patterns consistent with temporal retinal suppression in exotropia and nasal retinal suppression in esotropia.
    • Fixation-switching occurred when targets were beyond the midpoint between the eyes' lines of sight.
    • A surprisingly broad zone (>10°) allowed monkeys to acquire targets with either eye, indicating a lack of sharp fixation zone borders.

    Conclusions:

    • Spatial fixation patterns in strabismus can be explained by a decision framework where the brain accesses and chooses between retinal error information from each eye.
    • Near the visual midpoint, equal retinal error strength from both eyes leads to variable eye choice for fixation.
    • This suggests a dynamic oculomotor system capable of adapting to strabismic conditions.