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Related Experiment Videos

Sulfur revisited.

A N Lin1, R J Reimer, D M Carter

  • 1Laboratory for Investigative Dermatology, Rockefeller University, New York, NY 10021.

Journal of the American Academy of Dermatology
|March 1, 1988
PubMed
Summary
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Sulfur effectively treats skin conditions by breaking down keratin. Smaller sulfur particles enhance therapeutic benefits and skin penetration.

Area of Science:

  • Dermatology
  • Dermatologic Therapeutics

Background:

  • Sulfur is a traditional remedy for various skin conditions.
  • Its therapeutic action is linked to keratolytic properties and interaction with skin cells.

Purpose of the Study:

  • To elucidate the mechanism of sulfur's keratolytic action.
  • To investigate the relationship between sulfur particle size and therapeutic efficacy.
  • To review sulfur's histological effects and safety profile in dermatologic applications.

Main Methods:

  • Review of existing literature on sulfur's dermatologic applications.
  • Analysis of studies investigating sulfur's interaction with keratinocytes.
  • Examination of histological changes induced by topical sulfur application.
  • Assessment of systemic absorption and adverse effects.

Related Experiment Videos

Main Results:

  • Sulfur's keratolytic effect stems from hydrogen sulfide formation via interaction with keratinocytes.
  • Smaller sulfur particle size correlates with increased interaction and therapeutic efficacy.
  • Topical sulfur induces hyperkeratosis, acanthosis, and dermal vasculature changes.
  • Comedogenicity findings are inconsistent across studies; systemic absorption is minimal (approx. 1%).
  • Adverse effects are rare, primarily cutaneous, with rare severe outcomes in infants.

Conclusions:

  • Sulfur's efficacy in dermatology is particle-size dependent.
  • It demonstrates significant histological effects on the skin.
  • While generally safe, caution is advised, especially in infants.