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Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
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Augmentation of antitubercular therapy with IFNγ in a patient with dominant partial IFNγ receptor 1 deficiency

Kanako Takeda1, Toshinao Kawai2, Yumiko Nakazawa2

  • 1Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan.

Clinical Immunology (Orlando, Fla.)
|February 11, 2014
PubMed

Osteomyelitis due to Mycobacterium bovis Bacille Calmette-Guerin (BCG) often develops in patients with interferon-γ receptor 1 (IFNγR1) deficiency. In these patients, susceptibility appears to be caused by impaired interleukin-12- and IFNγ-mediated immunity. Here we report the case of a one-year-old girl with dominant partial IFNγR1 deficiency who suffered from lymphadenitis and multiple sites of osteomyelitis due to BCG infection. She was allergic to isoniazid and rifampicin--the prescribed standard treatment--and required prior desensitization therapy. She was subsequently treated with these drugs, but her symptoms did not improve. IFNγ therapy was added to the antitubercular therapy, increasing the serum level of IFNγ and leading to the resolution of the lymphadenitis and osteomyelitis. In conclusion, high dose IFNγ therapy in combination with antitubercular drugs led to resolution of BCG infection in a patient with dominant partial IFNγ deficiency.

Keywords:
Interferon-γInterferon-γ receptor 1 deficiency;Mendelian susceptibility to mycobacterial diseases;Mycobacterium bovis Bacille Calmette–Guerin;Osteomyelitis;

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