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In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth
Published on: June 28, 2019
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Supramolecular polymeric peptide amphiphile vesicles for the encapsulation of basic fibroblast growth factor
Xian Jun Loh1, Jesús del Barrio, Tung-Chun Lee
1Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. oas23@cam.ac.uk.
Chemical Communications (Cambridge, England)
|February 11, 2014
Abstract:
The synthesis of a supramolecular double hydrophilic peptide-conjugated polymer held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent temperature triggered self-assembly into vesicles are described. Basic fibroblast growth factor can be easily loaded into the vesicles under benign conditions and their bioactivities can be preserved without the need for excipients such as heparin.
