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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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More than just metastases: a practical approach to solid mesenteric masses.

Abbey J Winant1, Amar Vora, Paula S Ginter

  • 1Department of Radiology, New York Presbyterian Hospital, Weill Cornell Medical College, 525 East 68th St., New York, NY, 10065, USA.

Abdominal Imaging
|February 11, 2014
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Summary

Solid mesenteric masses can arise from various causes, from benign to malignant. This review details four key conditions—sclerosing mesenteritis, carcinoid, desmoid, and gastrointestinal stromal tumors—to aid in diagnosis using imaging characteristics.

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Area of Science:

  • Radiology
  • Pathology
  • Gastroenterology

Background:

  • Abdominal mesenteries are crucial peritoneal structures prone to diverse abnormalities.
  • Solid mesenteric masses present a diagnostic challenge due to varied etiologies, ranging from benign to highly malignant conditions.

Purpose of the Study:

  • To review four distinct pathologic entities manifesting as solid mesenteric masses: sclerosing mesenteritis, carcinoid tumors, desmoid tumors, and gastrointestinal stromal tumors.
  • To present a systematic approach for radiographic characterization of solid mesenteric masses.

Main Methods:

  • Review of imaging findings for sclerosing mesenteritis, carcinoid tumors, desmoid tumors, and gastrointestinal stromal tumors.
  • Analysis of lesion morphology, locoregional effects, and distant findings on abdominal imaging.

Main Results:

  • Metastases are the most frequent cause of solid mesenteric masses.
  • Sclerosing mesenteritis, carcinoid tumors, desmoid tumors, and GISTs represent important differential diagnoses with distinct imaging features.
  • Radiographic characterization involves evaluating lesion morphology and associated locoregional/distant findings.

Conclusions:

  • A systematic imaging approach is essential for differentiating various causes of solid mesenteric masses.
  • Understanding the specific radiographic features of these four entities improves diagnostic accuracy.
  • Accurate diagnosis of solid mesenteric masses is critical for appropriate patient management.