After myringotomy, can topical Mesna application be an alternative method to ventilation tube application?

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Rifat Karli1, Fatih Ilkaya, Arzu Karli

  • 1Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey, rifatkarli@yahoo.com.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|February 11, 2014
PubMed

Insights

Sodium-2-mercaptoethanesulfonate (Mesna) delays eardrum perforation healing in rats. This study suggests Mesna application may prolong recovery from middle-ear issues by extending tympanic membrane closure time.

Area of Science:

  • Otolaryngology
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Sodium-2-mercaptoethanesulfonate (Mesna) is recognized for its mucolytic properties and use in chemical tissue dissection during otological surgery.
  • Understanding Mesna's impact on tympanic membrane healing is crucial for optimizing otological surgical outcomes.

Purpose of the Study:

  • To investigate the effect of Mesna on the healing time of tympanic membrane perforations in an experimental animal model.
  • To determine if Mesna influences the rate of eardrum closure following myringotomy.

Main Methods:

  • A myringotomy model was created on rat tympanic membranes.
  • Rats were divided into three groups: Mesna-administered, saline-administered (control), and native (no treatment).
  • Mesna or saline was applied locally post-myringotomy, with healing assessed via otoendoscopy over seven days.

Main Results:

  • The study found a significantly longer tympanic membrane closing time in the Mesna-administered group compared to both the saline and native control groups.
  • Mesna application was associated with a delay in the resolution of tympanic membrane perforations.

Conclusions:

  • Local application of Mesna following myringotomy may prolong the recovery duration of middle-ear pathologies by delaying tympanic membrane perforation closure.
  • Mesna is not a suitable alternative for ventilation tube application in managing middle-ear conditions.

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