Related Experiment Video
Updated: May 3, 2026
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
[A novel human leukocyte antigen-A*33:44 allele revealed by sequence analysis]
Haoqiang Ding1, Xin Ye, Yingfeng Huang
1Institute of Blood Transfusion, Guangzhou Blood Center, Guangzhou, Guangdong 510095, P.R.China. 779684055@qq.com.
Objective:
To analyze the sequence of a novel human leukocyte antigen (HLA)-A*33:44 allele.
Methods:
A novel HLA-A allele was found by double-stranded sequencing combined with single-stranded sequencing. The frequency of the novel allele was determined by population survey.
Results:
Genomic sequence of this novel HLA-A*33:44 allele (accession No. HQ873871) has differed from HLA-B*33:03:01 by one nucleotide in exon 4, which resulted in nt 866 G→ A substitution, which results in an amino acid substitution from Gly(GGT) to Asp(GAT) at codon 265. This alternation is a new single nucleotide polymorphism compared with other HLA-A alleles. The frequency of this new allele is less than 0.0003 in Chinese Han population.
Conclusion:
A mutation has been found in exon 4 of the novel HLA-A*33:44 allele, which may provide more information for HLA gene study.
More Related Videos
Related Concept Videos
02:41Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
02:20Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
01:49Multiple Allele Traits