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Schistosomiasis.

Matthew S Tucker1, Laksiri B Karunaratne1, Fred A Lewis1

  • 1Biomedical Research Institute, Rockville, Maryland.

Current Protocols in Immunology
|February 11, 2014
PubMed
Summary
This summary is machine-generated.

Schistosomiasis, a major parasitic disease, impacts millions globally. This research details the life cycles of key schistosome species, crucial for understanding and combating the disease.

Keywords:
haematobiumjaponicummansonischistosomiasissnail

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Area of Science:

  • Parasitology
  • Immunology
  • Tropical Medicine

Background:

  • Schistosomiasis is a significant global health concern, ranking second in parasitic disease impact.
  • Affecting over 200 million people worldwide, it causes an estimated 200,000 deaths annually.
  • Key human-infecting species include Schistosoma mansoni, S. japonicum, and S. haematobium, leading to conditions like liver fibrosis and bladder dysfunction.

Purpose of the Study:

  • To provide a comprehensive overview of maintaining the life cycles of major human schistosome parasites.
  • To detail methodologies for immunological research on schistosomiasis.
  • To cover essential aspects of parasite and host maintenance for Schistosoma species.

Main Methods:

  • Preparation of schistosome egg antigen.
  • Maintenance of intermediate snail hosts.
  • Infection protocols for definitive and intermediate hosts.

Main Results:

  • Detailed protocols for the cultivation and propagation of Schistosoma mansoni.
  • Included are methods applicable to Schistosoma japonicum and Schistosoma haematobium.
  • Established procedures for generating essential reagents for schistosomiasis research.

Conclusions:

  • Understanding and maintaining schistosome life cycles are fundamental for immunological studies.
  • The provided methods facilitate research into the pathology and control of schistosomiasis.
  • This unit serves as a vital resource for researchers in parasitology and tropical medicine.