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Targeted therapy in gliomas

Mohamed Ali Hamza1, Mark Gilbert

  • 1The University of Texas MD Anderson Cancer Center, Houston, TX, USA, m_hamza67@hotmail.com.

Current Oncology Reports
|February 11, 2014
PubMed

Insights

Despite treatment advances, malignant glioma survival remains poor due to tumor heterogeneity. This review highlights molecular targets and clinical trial outcomes for targeted glioma therapies, aiming to improve patient survival.

Area of Science:

  • Neuro-oncology
  • Molecular biology
  • Clinical pharmacology

Background:

  • Malignant gliomas have poor survival outcomes despite current multimodal treatments.
  • Tumor molecular heterogeneity drives treatment resistance in gliomas.
  • Advances in understanding glioma pathogenesis have identified novel therapeutic targets.

Purpose of the Study:

  • To review key molecular targets for glioma therapy.
  • To summarize clinical trial outcomes for targeted agents in glioma patients.
  • To assess the potential of targeted therapies to improve survival.

Main Methods:

  • Literature search of published clinical trials.
  • Review of studies on molecular targets in glioma.
  • Synthesis of data on targeted therapeutic agents and patient outcomes.

Main Results:

  • Several molecular targets have been identified in glioma.
  • Clinical trials of targeted agents show varying efficacy.
  • Targeted therapies offer potential for improved glioma treatment.

Conclusions:

  • Targeted molecular therapies represent a promising strategy for malignant gliomas.
  • Further research and clinical trials are needed to optimize targeted treatment approaches.
  • Personalized medicine based on molecular profiling may enhance glioma patient outcomes.

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