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Electroporation-mediated intradermal delivery of DNA vaccines in nonhuman primates
Lucille Adam1, Roger Le Grand, Frédéric Martinon
1Division of Immuno-Virology, CEA, Institute for Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.
Abstract:
Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development of human vaccines, using noninvasive needleless electrodes.
