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Related Experiment Video

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Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
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Quantitative cerebral blood flow measurements using MRI.

Eric R Muir1, Lora Talley Watts, Yash Vardhan Tiwari

  • 1Department of Ophthalmology, Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)
|February 11, 2014
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Summary

Magnetic resonance imaging offers a noninvasive way to measure rodent cerebral blood flow. This summary covers dynamic susceptibility contrast (DSC) perfusion MRI and arterial spin labeling (ASL) perfusion MRI methods.

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Area of Science:

  • Neuroimaging
  • Physiology
  • Biomedical Engineering

Background:

  • Cerebral blood flow (CBF) is crucial for brain function and health.
  • Quantitative, noninvasive imaging methods are needed for CBF assessment.
  • Magnetic resonance imaging (MRI) provides such capabilities.

Purpose of the Study:

  • To describe the application of two common MRI techniques for measuring rodent cerebral blood flow.
  • To detail the methods, analysis, and considerations for using DSC and ASL perfusion MRI in rodents.

Main Methods:

  • Dynamic Susceptibility Contrast (DSC) perfusion MRI.
  • Arterial Spin Labeling (ASL) perfusion MRI.
  • Application of these techniques in rodent models.

Main Results:

  • Demonstration of quantitative CBF measurement using DSC and ASL MRI.
  • Outline of specific protocols and analytical approaches for rodent studies.
  • Identification of key factors influencing data acquisition and interpretation.

Conclusions:

  • DSC and ASL perfusion MRI are valuable tools for quantitative, noninvasive CBF assessment in rodents.
  • Careful methodology and analysis are essential for reliable results.
  • These techniques facilitate preclinical research into cerebrovascular diseases and treatments.