Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

6.9K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.9K
Rab Cascades01:25

Rab Cascades

2.8K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
2.8K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

4.4K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
4.4K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

91.4K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
91.4K
GTPases and their Regulation02:14

GTPases and their Regulation

7.9K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
7.9K
GTPases and their Regulation02:14

GTPases and their Regulation

2.4K
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rethinking the economics and flexibility of U.S. nuclear power through hydrogen integration and policy support.

Nature communications·2026
Same author

da Vinci-facilitated harvesting of pericardium for Ozaki procedure through partial sternotomy.

Multimedia manual of cardiothoracic surgery : MMCTS·2026
Same author

Corrigendum to Uncomplicated Type B Aortic Dissection: A European Multicentre Cross-Sectional Evaluation [Ann Vasc Surg 2025; 114: 340-349].

Annals of vascular surgery·2026
Same author

Intraoperative antithrombotic drug removal during heart transplantation: A case series from the International Safe and Timely Antithrombotic Removal (STAR) registry.

JHLT open·2025
Same author

Pulmonary valve neo-reconstruction using the Ozaki technique in an adapted Ross procedure: case report.

European heart journal. Case reports·2025
Same author

CytoSorb hemoadsorption of apixaban during cardio-pulmonary bypass for heart transplantation.

JHLT open·2025

Related Experiment Video

Updated: May 3, 2026

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

4.8K

Reply to Girdauskas and Rouman

Jaroslav Benedik1, Daniel Wendt2, Kevin Pilarczyk2

  • 1Department of Thoracic and Cardiovascular Surgery, West German Heart Center, University of Essen, Essen, Germany jaroslav.benedik@uk-essen.de.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|February 11, 2014
PubMed
Summary

No abstract available in PubMed .

Keywords:
Aortic valve dysfunctionAortic wallAortic wall cohesion testingDissection

More Related Videos

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury
07:46

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury

Published on: June 29, 2015

10.3K
CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

1.8K

Related Experiment Videos

Last Updated: May 3, 2026

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

4.8K
Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury
07:46

Triggering Reactive Gliosis In Vivo by a Forebrain Stab Injury

Published on: June 29, 2015

10.3K
CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

1.8K