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Updated: May 3, 2026
Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
DNA from human polyomaviruses, TSPyV, MWPyV, HPyV6, 7 and 9 was not detected in primary mucosal melanomas
Torbjörn Ramqvist1, Cecilia Nordfors, Tina Dalianis
1Department Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK R8:01, SE-171 76 Stockholm, Sweden. torbjorn.ramqvist@ki.se.
Background/Aim:
Mucosal melanomas arise in non UV-light exposed areas and causative factors are yet unknown. Human polyomaviruses (HPyVs) are rapidly increasing in numbers and are potentially oncogenic, as has been established for MCPyV in Merkel cell carcinoma, an unusual skin cancer type. The aim of the present study was to investigate the association between TSPyV, MWPyV, HPyV6, 7 and 9 and mucosal melanoma.
Materials And Methods:
Fifty-five mucosal melanomas, were analyzed by a Luminex assay, for the presence of 10 HPyVs (BKPyV, JCPyV, KIPyV, WUPyV, TSPyV, MWPyV, HPyV6, 7 and 9) and two primate viruses (SV40 and LPyV).
Results:
In 37 samples the DNA quality was satisfactory for analysis. However, none of the samples analyzed were positive for any of the examined viruses.
Conclusion:
None of the above-analyzed HPyVs were detected in mucosal melanoma samples, and they are for this reason unlikely to play a major role in the development of this tumor type.
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