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Tumor marker score for prognostication of early-stage squamous cell cervical cancer
1Center for Clinical Research, Nissers vag 3, 79182 Falun, Sweden. dan.hellberg@ltdalarna.se and Associate Professor Tibor Tot, Department of Pathology and Clinical Cytology, Falun Hospital, 79182 Falun, Sweden.
Background/Aim:
Histopathological and clinical scores to predict prognosis in cervical cancer have been of limited value. In the present study a tumor marker expression score was evaluated for prognostication in early-stage cervical cancer.
Materials And Methods:
The entire study population included 128 women with invasive squamous cell cervical cancer followed-up for at least 10 years.
Results:
Expression of 12 tumor markers (epidermal growth factor receptor (EGFR), Ki-67, c-MYC, p53, p27, E-cadherin, CD44, vascular endothelial growth factor receptor (VEGF), cyclooxygenase-2 (COX2), CD4, and leucine-rich immunoglobulin-like repeats-1 (LRIG1) and LRIG2, considered relevant for cervical cancer prognostication was evaluated by immunohistochemistry. Expression of five markers, LRIG1, LRIG2, p53, COX2 and c-MYC were useful to make a prognostication score, ranging from 0 to 5. Score 0-1 correlated to less than 5% 10-year mortality, while the mortality rate of those with score 4-5 approached 70%; those with score 2 formed an intermediate group. Using different models, a high sensitivity, specificity, positive predictive value and negative predictive value was attained.
Conclusion:
Tumor marker scoring could be an adjunct to histopathological and clinical parameters in prognostication of early-stage cervical cancer.