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Updated: May 3, 2026
Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
A Long-term follow-up study of 91 cases with ovarian granulosa cell tumors
Seung-Hyuk Shim1, Sun Joo Lee, Dae-Yeon Kim
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 388-1, Pungnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea. nastassja@naver.com.
Aim:
To evaluate the prognostic factors of ovarian granulosa cell tumors (GCTs) and treatment outcomes in recurrent GCT cases.
Patients And Methods:
We retrospectively reviewed 91 patients with GCT who were treated in two tertiary Centers between 1989 and 2011.
Results:
Eighty patients had stage I tumors, five had stage II, and six had stage III. There were 15 cases of recurrence with a median follow-up time of 58 (3-254) months. Multivariate analysis identified greater tumor size and postoperative residual tumor as independent risk factors for recurrence. Twelve patients underwent secondary surgery at first recurrence. At a median follow-up of 50 (4-185) months from first recurrence, the 5-year survival was 60% for patients with and 100% for those without residual tumor after secondary surgery, respectively (p=0.018, log-rank test).
Conclusion:
Complete cytoreduction is an important prognostic factor for recurrent cases as well as initial treatment of GCT.
