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Expression of the rat myosin light-chain 2 gene in transgenic mice: stage specificity, developmental regulation, and
1Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Molecular and Cellular Biology
|February 1, 1988
Abstract:
The expression of the rat skeletal myosin light-chain 2 gene in two transgenic strains was tissue specific and stage specific. However, the temporal regulation during development of the transgene was different from that of the endogenous gene. Surprisingly, in one strain, the expression of the transgene was associated with a significant down-regulation of the endogenous gene. The possible mechanisms to account for the suppression of the endogenous gene and the potential implications of this suppression are discussed.