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Updated: May 3, 2026
Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
Published on: November 10, 2017
Lighting up cells with lanthanide self-assembled helicates
1Institute of Chemical Sciences and Engineering , École Polytechnique Fédérale de Lausanne , BCH 1402, 1015 Lausanne , Switzerland.
Abstract:
Lanthanide bioprobes and bioconjugates are ideal luminescent stains in view of their low propensity to photobleaching, sharp emission lines and long excited state lifetimes permitting time-resolved detection for enhanced sensitivity. We show here how the interplay between physical, chemical and biochemical properties allied to microfluidics engineering leads to self-assembled dinuclear lanthanide luminescent probes illuminating live cells and selectively detecting biomarkers expressed by cancerous human breast cells.
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