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A Double-edged Sword: Uric Acid and Neurological Disorders
Pu Fang1, Xinyuan Li2, Jin Jun Luo3
1Center for Metabolic Disease Research, Temple University School of Medicine, Philadelphia PA, 19140, USA.
Abstract:
Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental to the neurons because of its induction it impairs antioxidant capacity in the cell. High levels of UA, on the other hand, lead to an inflammatory response contributing to gout or neuroprotection. In this review, we summarize this biphasic function of uric acid and highlight potential therapeutic targets to treat UA-related neurological diseases.
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