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Discriminating extrusive and bulging disk herniations by using serum hs CRP
S Talghini1, Amir Vahedi1, I Lotfinia2
1Department of Pathology, Tabriz University of Medical Sciences, Sina Hospital, Tabriz, Iran.
Pakistan Journal of Biological Sciences : PJBS
|February 12, 2014
Summary
Serum high-sensitivity C-Reactive Protein (hs CRP) levels are significantly higher in patients with extrusive lumbar disk herniation compared to bulging types. A hs CRP cut-off of 2.6 mg/dL may help differentiate these herniation types.
Area of Science:
- Biochemistry
- Orthopedics
- Inflammatory Markers
Background:
- Inflammation around nerve roots is a hallmark of disk herniation.
- Serum C-Reactive Protein (CRP) is a known inflammatory marker.
- Previous research suggests a potential association between CRP and disk herniation.
Purpose of the Study:
- To compare serum high-sensitivity CRP (hs CRP) levels between extrusive and bulging lumbar disk herniation.
- To determine if hs CRP can differentiate between these two types of disk herniation.
- To identify a potential hs CRP cut-off value for distinguishing herniation types.
Main Methods:
- A prospective study involving 62 patients undergoing lumbar disk herniation surgery.
- Patients were categorized into extrusion (n=34) and bulging (n=28) groups.
- Pre-operative serum hs CRP levels were measured using turbidimetric immunoassay.
Main Results:
- Mean serum hs CRP was significantly higher in the extrusion group (3.56 mg/dL) compared to the bulging group (0.74 mg/dL) (p < 0.001).
- Patient sex and age were comparable between the two groups.
- A hs CRP cut-off of 2.6 mg/dL demonstrated 66% sensitivity and 63% specificity in identifying extrusive herniation.
Conclusions:
- Mean serum hs CRP levels are significantly elevated in patients with extrusive disk herniation versus bulging disk herniation.
- The identified hs CRP cut-off value of 2.6 mg/dL may serve as a preliminary indicator for herniation type.
- This finding could aid in pre-imaging assessment and clinical decision-making for lumbar disk herniation.
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