Related Experiment Video
Updated: May 3, 2026

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion
Published on: May 9, 2025
Effect of bulk aging on surface diffusion of glasses
Caleb W Brian1, Lei Zhu1, Lian Yu1
1Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Abstract:
The effect of physical aging on surface diffusion has been determined for two organic glasses, Indomethacin and Nifedipine. The two systems exhibit similar aging kinetics typical of organic glasses. Surface diffusivity remains unchanged despite significant bulk aging that nearly equilibrates the systems and increases the bulk relaxation time by orders of magnitude. The finding is relevant for understanding the stability of amorphous materials and the formation of low-energy glasses by vapor deposition.
More Related Videos
Related Concept Videos
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Porosity and Absorption of Aggregate
When all pores in an aggregate are filled with water, the aggregate is considered saturated and surface-dry. If left in dry air, water will evaporate until the...
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Unsoundness of Aggregate due to Volume Change

