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Updated: May 3, 2026

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics
Published on: June 17, 2022
The expanding role of paper in point-of-care diagnostics
Scott T Phillips1, Gregory G Lewis
1Department of Chemistry, The Pennsylvania State University , University Park, PA 16802 , USA.
Abstract:
This editorial discusses the expanding role of paper as a platform on which to build new point-of-care assays, particularly those intended for use in resource-limited settings. Successful diagnostics for use in these environments require a low-cost platform (possibly paper) as well as new assay strategies, reagents and materials for achieving selectivity and sensitivity. Paper provides a common platform for bringing these components together and serves as a low-cost medium for prototyping new point-of-care assays.
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