Related Experiment Video

Updated: May 3, 2026

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.9K

Cognitive functioning in young children with type 1 diabetes

M Allison Cato1, Nelly Mauras2, Jodie Ambrosino3

  • 11 Divsions of Neurology, Nemours Children's Clinic, Jacksonville, Florida.

Journal of the International Neuropsychological Society : JINS
|February 12, 2014
PubMed

Insights

Children with type 1 diabetes (T1D) show subtle cognitive differences, particularly in executive functions, compared to healthy peers. Glycemic history may influence these cognitive outcomes in young children.

Area of Science:

  • Pediatric Endocrinology
  • Neuropsychology
  • Child Development

Background:

  • Type 1 diabetes (T1D) is a chronic condition affecting children.
  • Cognitive function is crucial for development and academic success.
  • Understanding T1D's impact on cognition is vital for early intervention.

Purpose of the Study:

  • To assess cognitive functioning in young children with T1D.
  • To investigate the influence of glycemic history on cognitive performance.
  • To compare cognitive domains between children with T1D and healthy controls.

Main Methods:

  • Neuropsychological evaluation of 216 children (ages 4-10).
  • Included healthy controls (n=72) and T1D cohort (n=144).
  • Assessed IQ, Executive Functions, Learning/Memory, Processing Speed, and behavioral symptoms; collected glycemic history.

Main Results:

  • Children with T1D trended lower in IQ and Executive Functions (p=0.02).
  • No significant differences in Learning/Memory or Processing Speed.
  • Parents reported more depressive/somatic symptoms in children with T1D (p<0.001).
  • Hyperglycemia trends associated with Executive Functions, IQ, and Learning/Memory.

Conclusions:

  • Subtle cognitive differences may exist in young children with T1D early in the disease course.
  • Glycemic history shows a potential association with cognitive function.
  • Longitudinal studies are needed to track cognitive changes over time.

More Related Videos

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.2K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.6K

Related Concept Videos

Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1...
45
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the...
26
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
75
Information Processing Approach01:30

Information Processing Approach

The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
889
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.9K