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Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

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Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
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Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Diabetic Neuropathy01:22

Diabetic Neuropathy

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

679
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Carbohydrate Metabolism01:36

Carbohydrate Metabolism

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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Related Experiment Video

Updated: May 3, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

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Is diabetic nephropathy reversible?

Paola Fioretto1, Isabella Barzon1, Michael Mauer2

  • 1Department of Medicine, University of Padova, Italy.

Diabetes Research and Clinical Practice
|February 12, 2014
PubMed
Summary
This summary is machine-generated.

Diabetic nephropathy lesions, previously thought irreversible, show significant reversal in kidney structure 10 years after pancreas transplantation. This study demonstrates the potential for substantial kidney remodeling with long-term blood sugar normalization in type 1 diabetes patients.

Keywords:
Diabetic nephropathyGlomerular lesionsGlycemic controlMorphometric analysisPancreas transplantation

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Area of Science:

  • Nephrology
  • Endocrinology
  • Transplantation Immunology

Background:

  • Diabetic nephropathy is a leading cause of kidney failure.
  • Existing treatments for diabetic nephropathy primarily manage symptoms and slow progression.
  • The potential for reversing established diabetic kidney lesions has been unclear.

Purpose of the Study:

  • To investigate the reversibility of diabetic nephropathy lesions in humans.
  • To assess the long-term effects of pancreas transplantation on renal structure.
  • To determine if sustained normoglycemia can reverse established kidney damage.

Main Methods:

  • Studied renal structure in eight non-uremic type 1 diabetes patients.
  • Patients underwent pancreas transplantation alone.
  • Renal biopsies were analyzed before transplantation and at 5 and 10 years post-transplant.

Main Results:

  • Glomerular lesions showed no significant change at 5 years post-transplantation.
  • Marked improvement in glomerular lesions was observed at 10 years, with normalization in most patients.
  • Similar improvements were noted in tubular and interstitial lesions.

Conclusions:

  • Diabetic nephropathy lesions are reversible in humans.
  • Long-term normalization of blood glucose via pancreas transplantation promotes substantial kidney structural remodeling.
  • Pancreas transplantation offers a potential therapeutic strategy for reversing diabetic kidney disease.