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Neutrophil function in psoriasis: effects of retinoids
B I Coble1, C Dahlgren, L Molin
1Department of Dermatology, Linköping University Medical School, Sweden.
Acta Dermato-Venereologica
|January 1, 1987
Summary
Pustular psoriasis enhances neutrophil oxidative response, which is inhibited by retinoids like retinoic acid. This suggests retinoids may reduce inflammation by modulating neutrophil activation and function in psoriasis.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis involves altered immune cell function, particularly neutrophils.
- Neutrophil oxidative responses are implicated in inflammatory skin conditions like pustular psoriasis.
Purpose of the Study:
- To investigate the oxidative response of neutrophils in pustular psoriasis.
- To determine the effect of various retinoid compounds on neutrophil function in psoriasis.
Main Methods:
- Assessed neutrophil chemiluminescence response to chemotactic peptides and phorbol myristate acetate in active pustular psoriasis.
- Evaluated the impact of tretinoin (retinoic acid), isotretinoin, etretinate, and Ro 10-1670 on neutrophil function in vitro and in vivo.
- Measured Fc-mediated and C3bi-mediated phagocytosis.
Main Results:
- Neutrophil chemiluminescence was enhanced in active pustular psoriasis, correlating with pustule development.
- Cells from psoriasis vulgaris patients showed normal chemiluminescence.
- Tretinoin and isotretinoin significantly inhibited chemiluminescence in primed neutrophils.
- Retinoic acid inhibited Fc-mediated phagocytosis but not C3bi-mediated phagocytosis.
Conclusions:
- Enhanced neutrophil oxidative response in pustular psoriasis may contribute to disease pathogenesis.
- Retinoids, particularly retinoic acid and isotretinoin, can inhibit neutrophil activation and function.
- These findings suggest a potential anti-inflammatory mechanism for retinoids in psoriasis through modulation of neutrophil activity.