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PUVA therapy for photosensitive psoriasis.

A M Ros1, G Wennersten

  • 1Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.

Acta Dermato-Venereologica
|January 1, 1987
PubMed
Summary
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Oral photochemotherapy with psoralens and UVA (PUVA) effectively prevents light-sensitive psoriasis flares. This treatment showed 80% efficacy in patients with photosensitive psoriasis, including those with a history of polymorphous light eruption (PMLE).

Area of Science:

  • Dermatology
  • Photomedicine

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Photosensitive psoriasis presents unique challenges due to UV light exacerbation.
  • Polymorphous light eruption (PMLE) can precede or coexist with psoriasis.

Purpose of the Study:

  • To evaluate the prophylactic efficacy of oral photochemotherapy (PUVA) for light-sensitive psoriasis.
  • To assess PUVA's effectiveness in patients with a history of PMLE developing into psoriasis.

Main Methods:

  • Fifteen patients with photosensitive psoriasis were included.
  • Ten patients with a history of PMLE were treated with trimethylpsoralen (TMP) and UVA.
  • Five patients without prior PMLE were treated with 8-methoxypsoralen (8-MOP) or TMP.

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Main Results:

  • An overall efficacy of 80% was observed.
  • 9/10 patients with a history of PMLE showed good to excellent results.
  • 3/5 patients without prior PMLE also responded well.
  • TMP therapy did not heal existing psoriatic lesions, unlike 8-MOP.

Conclusions:

  • Oral PUVA therapy is effective in preventing flares of light-sensitive psoriasis.
  • The treatment is particularly beneficial for patients with photosensitive psoriasis and a history of PMLE.
  • 8-MOP may be more effective for treating existing psoriatic lesions compared to TMP.