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Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
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Published on: July 25, 2017

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Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl

Jinwei Zhu1, Yuan Shang1, Qingwen Wan2

  • 1Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Cell Research
|February 12, 2014
PubMed
Summary

Discs Large (Dlg) and Lethal giant larvae (Lgl) proteins physically interact in a phosphorylation-dependent manner. This finding elucidates the Scribble complex formation mechanism and aids in developing targeted cancer therapies.

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