Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Focusing of Light in the Eye01:16

Focusing of Light in the Eye

6.2K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
6.2K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

16.0K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
16.0K
Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loganin triggers ferroptosis in renal cell carcinoma by targeting the IGF2BP2/HMOX1 axis in an m6A-dependent manner.

Biochemical pharmacology·2026
Same author

Validating free spectral range tracking as a robust method for mitigating artifacts in VSC kinetics.

RSC advances·2026
Same author

RBM14 drives prostate cancer metastasis via stabilizing HK2 mRNA to activate glycolysis and H3K18 lactylation.

Cell death discovery·2026
Same author

The role of the LncRNA XIST/miR-15a-5p/MN1 signaling axis in gender disparities in bladder cancer prognosis.

Frontiers in immunology·2025
Same author

Human Single-Cell RNA-Sequencing Data Supports the Hypothesis of X Chromosome Insensitivity but Is Ineffective in Testing the Dosage Compensation Model.

Molecular biology and evolution·2025
Same author

RBM19 promotes the progression of prostate cancer under docetaxel treatment via SNHG21/PIM1 axis.

Cell biology and toxicology·2024
Same journal

Multifunctional reconfigurable terahertz metasurface based on vanadium dioxide phase transition: achieving broadband absorption and efficient polarization conversion.

Applied optics·2026
Same journal

High-Q-factor electromagnetically induced transparency utilizing quasi-bound states in the continuum in an all-dielectric terahertz metasurface.

Applied optics·2026
Same journal

Automated stitching interferometry for high-precision metrology of X-ray mirrors.

Applied optics·2026
Same journal

Experimental demonstration of an approach to designing a metal-dielectric DBR resonant cavity structure.

Applied optics·2026
Same journal

High-precision wavefront reconstruction from a single-shot interferogram using a physics-driven hybrid feature calibration network.

Applied optics·2026
Same journal

Ultra-high-Q Fano resonance based on coupled topological corner states in Kagome photonic crystals.

Applied optics·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
05:46

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Published on: September 20, 2024

896

Intraocular lens based on double-liquid variable-focus lens.

Runling Peng, Yifan Li, Shuilan Hu

    Applied Optics
    |February 12, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Researchers replaced the human eye

    More Related Videos

    Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
    11:49

    Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

    Published on: March 8, 2019

    13.7K
    Indoor Experimental Assessment of the Efficiency and Irradiance Spot of the Achromatic Doublet on Glass ADG Fresnel Lens for Concentrating Photovoltaics
    09:00

    Indoor Experimental Assessment of the Efficiency and Irradiance Spot of the Achromatic Doublet on Glass ADG Fresnel Lens for Concentrating Photovoltaics

    Published on: October 27, 2017

    11.6K

    Related Experiment Videos

    Last Updated: May 3, 2026

    Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
    05:46

    Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

    Published on: September 20, 2024

    896
    Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
    11:49

    Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

    Published on: March 8, 2019

    13.7K
    Indoor Experimental Assessment of the Efficiency and Irradiance Spot of the Achromatic Doublet on Glass ADG Fresnel Lens for Concentrating Photovoltaics
    09:00

    Indoor Experimental Assessment of the Efficiency and Irradiance Spot of the Achromatic Doublet on Glass ADG Fresnel Lens for Concentrating Photovoltaics

    Published on: October 27, 2017

    11.6K

    Area of Science:

    • Ophthalmology and optical engineering.
    • Biomedical engineering and human eye modeling.

    Background:

    • The Gullstrand-Le Grand human eye model is a standard for optical simulations.
    • Current models often lack dynamic focus capabilities.
    • Variable-focus lenses offer potential for advanced ophthalmic applications.

    Purpose of the Study:

    • To develop and evaluate a pseudoaphakic eye model with a double-liquid variable-focus lens.
    • To improve the zoom range and resolution of the human eye model.
    • To reduce aberrations in the optical system.

    Main Methods:

    • Replaced the crystalline lens in the Gullstrand-Le Grand model with a double-liquid variable-focus lens.
    • Utilized theoretical analysis and experimental data for lens design.
    • Incorporated aspherical surfaces into the lens design within the Zemax optical software.
    • Optimized the system to minimize axial spherical aberration.

    Main Results:

    • The pseudoaphakic eye model demonstrated a significantly enhanced zoom range compared to normal human eyes.
    • The optimized system achieved a spot size on the image plane near the resolution limit of a normal human eye.
    • Introduction of aspherical surfaces effectively reduced axial spherical aberration.

    Conclusions:

    • A double-liquid variable-focus lens can successfully replace the crystalline lens in an eye model.
    • The developed pseudoaphakic eye model offers superior zoom capabilities and high resolution.
    • This approach holds promise for advanced vision correction and simulation technologies.