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Related Concept Videos

2D NMR: Homonuclear Correlation Spectroscopy (COSY)01:06

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Homonuclear correlation spectroscopy, or COSY, is a 2-dimensional NMR technique that provides information about coupled protons. Typically, the geminal and vicinal coupling are observed. For example, consider the COSY spectrum of ethyl acetate, where its 1D proton NMR spectrum is plotted along the vertical and horizontal axes with their corresponding chemical shift scale. Three spots on the diagonal corresponding to the three peaks in the 1D proton spectrum are called diagonal peaks. The COSY...
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2D NMR: Overview of Homonuclear Correlation Techniques01:16

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Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
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UV–Vis Spectroscopy: Woodward–Fieser Rules01:29

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UV–Visible absorption spectra of conjugated dienes arise from the lowest energy π → π* transitions. The light-absorbing part of the molecule is called the chromophore, and the substituents directly attached to the chromophore are called auxochromes. A strong correlation exists between the absorption maxima, λmax, and the structure of a conjugated π system. The Woodward–Fieser rules predict the value of λmax for a...
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Spectroscopy of Carboxylic Acid Derivatives01:26

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Infrared spectroscopy is primarily used to determine the types of bonds and functional groups. In carboxylic acid derivatives, a typical carbonyl bond absorption is observed around 1650–1850 cm−1. For esters, the absorption is recorded at around 1740 cm−1, while acid halides show the absorption at about 1800 cm−1. Another acid derivative, the acid anhydrides, exhibit two carbonyl absorption around 1760 cm−1 and 1820 cm−1, arising from the symmetrical and...
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IR Spectroscopy: Molecular Vibration Overview01:24

IR Spectroscopy: Molecular Vibration Overview

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When Infrared (IR) radiation passes through a covalently bonded molecule, the bonds transition from lower to higher vibrational levels. The fundamental vibrational motions that result in infrared absorption can be classified as stretching or bending vibrations.
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IR Spectrometers

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There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...
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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Optical coherence correlation spectroscopy (OCCS).

Stephane Broillet, Akihiro Sato, Stefan Geissbuehler

    Optics Express
    |February 12, 2014
    PubMed
    Summary
    This summary is machine-generated.

    We developed optical coherence correlation spectroscopy (OCCS) to study nanoparticle kinetics. This method enables simultaneous, spatially resolved measurements of diffusion and flow, advancing single-particle analysis.

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    Doppler Optical Coherence Tomography of Retinal Circulation
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    Area of Science:

    • Spectroscopy and optical measurement techniques.
    • Nanoparticle characterization and dynamics.

    Background:

    • Studying kinetic processes at the single-particle level is crucial for understanding complex systems.
    • Existing methods may lack simultaneous multi-volume sampling or spatial resolution.

    Purpose of the Study:

    • Introduce optical coherence correlation spectroscopy (OCCS) as a novel method.
    • Demonstrate OCCS's capability for single-particle kinetic analysis.
    • Highlight OCCS for spatially resolved diffusion and flow measurements.

    Main Methods:

    • Utilized spectral interferometry for simultaneous access to multiple sampling volumes.
    • Applied auto-correlation analysis to determine nanoparticle diffusion coefficients and concentrations.
    • Employed cross-correlation analysis between adjacent volumes to measure flow parameters.

    Main Results:

    • Successfully extracted diffusion coefficients and concentrations of nanoparticles across a wide concentration range.
    • Demonstrated the ability to measure flow parameters using cross-correlation analysis.
    • Validated OCCS for single-particle level kinetic reporting.

    Conclusions:

    • Optical coherence correlation spectroscopy (OCCS) is a powerful new technique for nanoparticle analysis.
    • OCCS provides simultaneous, spatially resolved measurements of diffusion and flow.
    • The method shows significant potential for advancing kinetic studies in various scientific fields.